Acne Help

Isotretinoin
The definitive treatment for severe acne

Starting at $99/Mo

The only prescription treatment that simultaneously addresses all four root causes of acne — sebum overproduction, follicular hyperkeratinization, bacterial colonization, and inflammation. When other treatments fail, isotretinoin delivers lasting clearance that no topical can achieve.

Licensed Metabolic MDsDaily oral capsuleResults in 4–6 months
Isotretinoin peptide therapy

Four causes. One treatment.

Most acne treatments target one or two causes. Isotretinoin is unique — it works at all four simultaneously, which is why it produces clearance that other treatments simply cannot match.

1

Sebaceous Glands

Sebum Reduction

Isotretinoin shrinks sebaceous (oil) glands by up to 90% and dramatically reduces sebum production — removing the primary fuel for acne. This reduction persists long after the course ends, which is why many patients experience permanent clearance.

Result: 90% reduction in sebum production, lasting months to years post-treatment

2

Follicular Keratinization

Pore Clearing

Normalizes the abnormal shedding of skin cells inside hair follicles (hyperkeratinization) that creates the clogged pores and microcomedones at the root of all acne. No pore clogging means no new pimples can form.

Result: Prevents microcomedone formation — stops acne at its origin

3

C. Acnes Colonization

Bacterial Control

By dramatically reducing sebum, isotretinoin removes the nutrient source that C. acnes (acne bacteria) requires to survive and multiply. The bacteria population collapses — without the need for antibiotics or external bactericidal agents.

Result: Significant reduction in C. acnes without developing antibiotic resistance

4

Inflammatory Cascade

Anti-Inflammatory

Directly reduces the inflammatory response that converts microcomedones into red, painful pimples, cysts, and nodules. This prevents the scarring and post-inflammatory hyperpigmentation that cause long-term skin damage.

Result: Reduced inflammatory lesions and prevention of permanent acne scarring

Clinical Benefits

What you can expect from Isotretinoin therapy

Long-lasting clearance

85% of patients achieve long-lasting or permanent acne clearance after a standard 5–6 month course — results no topical treatment can match.

90% sebum reduction

Shrinks sebaceous glands dramatically, eliminating the root cause of acne rather than just treating breakouts as they appear.

Prevents scarring

Stops inflammatory acne before it can cause the permanent dermal damage that leaves lasting scars, pits, and hyperpigmentation.

Treats all body acne

Effective for facial, back, chest, and shoulder acne simultaneously — the systemic delivery addresses all sebaceous glands at once.

Often permanent

Many patients require only one course. Some studies show up to 60–70% of patients never need retreatment after completing a full course.

Physician-monitored

Monthly check-ins with your dermatologist track your response, adjust dosing, and monitor for the rare side effects that require dose modification.

The Process

What to expect & when

Realistic timeline for Isotretinoin results

1

Weeks 1–4

Initial Adjustment Period

Some patients experience an initial flare as cell turnover accelerates. This is normal and temporary. Dryness of lips and skin typically begins and is easily managed with moisturizer.

2

Month 2

Sebum Reduction Begins

Visible reduction in skin oiliness. New breakouts begin to decrease as sebum production drops. Most patients notice their skin becoming less shiny.

3

Months 3–4

Dramatic Clearing

For most patients, this is when the transformation becomes obvious. Significant reduction in active lesions, fading of inflammatory redness, and improved skin texture.

4

Month 5–6

Standard Course Completion

Final weeks of treatment. Most patients are near-clear or fully clear at this point. Cumulative dose calculations help your physician determine course length.

5

Post-Treatment

Long-Term Clearance

The dramatic reduction in sebum production and sebaceous gland size persists long after stopping. 85% of patients maintain long-lasting improvement — many permanently.

Common questions

Everything you need to know about Isotretinoin therapy

Transparent Pricing

Consultation Fees

Physician-guided care with complete pricing clarity.

Generic Consultation

Includes Any & All Services

First Visit

$400

Follow-Up

$150

  • Complete health assessment
  • All service areas covered
  • Personalized treatment plan
  • Prescription if appropriate
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Specialized Consultation

Skin, Hair, Wellness, Labs, Galleri

First Visit

$300

Follow-Up

$150

  • Focused specialty review
  • Lab analysis included
  • Targeted treatment approach
  • Follow-up protocol
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Peptide Consultation

Weight loss & metabolic therapies

First Visit

$50

Follow-Up

$30

  • Metabolic assessment
  • GLP-1 or peptide evaluation
  • Dosing strategy
  • Prescription included
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Isotretinoin (Accutane®) for Severe Acne | Get Simple Health | Simple Health