Antidepressant Peptide
PE-22-28
Spadin analogue — natural antidepressant peptide
Starting at $285
PE-22-28 is an optimized analogue of Spadin — a naturally occurring antidepressant peptide derived from the propeptide of neurotensin. It inhibits TREK-1 potassium channels in the brain's serotonin pathways, producing rapid antidepressant effects with a uniquely rapid onset.
TREK-1 channel inhibition for mood optimization.
Serotonin Pathway
TREK-1 Inhibition
Inhibits TREK-1 potassium channels in the raphe nuclei (the brain's primary serotonin source), allowing more spontaneous serotonergic neuron firing — increasing serotonin release in key mood-regulating areas.
Result: Increased serotonin signaling for improved mood and stress resilience
BDNF Upregulation
Neuroplasticity
Like most effective antidepressant treatments, PE-22-28 upregulates BDNF in the hippocampus — promoting neuroplasticity that addresses the structural neural changes underlying depression.
Result: Enhanced neuroplasticity and hippocampal neurogenesis
Faster than SSRIs
Rapid Onset
Because it directly modulates the TREK-1 channel rather than blocking serotonin reuptake, effects can occur within days rather than the 4–6 weeks required for SSRI response.
Result: Antidepressant and mood-stabilizing effects within 1–2 weeks
Clinical Benefits
What you can expect from PE-22-28 therapy
Antidepressant effects
Rapid mood improvement through TREK-1 inhibition and serotonin pathway enhancement.
Rapid onset
Effects within 1–2 weeks — significantly faster than traditional antidepressants.
Neuroplasticity
BDNF upregulation promotes hippocampal neurogenesis — addressing structural brain changes in depression.
Natural mechanism
Based on a naturally occurring antidepressant peptide — a physiological approach to mood optimization.
Sleep improvement
Serotonin pathway optimization supports sleep quality and circadian rhythm health.
Minimal side effects
Novel mechanism distinct from SSRIs/SNRIs — typically without sexual side effects or withdrawal syndrome.
The Process
What to expect & when
Realistic timeline for PE-22-28 results
Days 3–7
Initial Mood Improvement
TREK-1 inhibition produces early serotonin pathway enhancement — mood often improves within the first week.
Weeks 1–3
Sustained Mood Stabilization
Serotonin signaling optimized. BDNF elevation begins supporting neuroplastic changes.
Weeks 3–8
Structural Improvements
Hippocampal neurogenesis and neuroplasticity produce more durable mood and cognitive improvements.
Common questions
Everything you need to know about PE-22-28 therapy
Transparent Pricing
Consultation Fees
Physician-guided care with complete pricing clarity.
Generic Consultation
Includes Any & All Services
First Visit
$400
Follow-Up
$150
- Complete health assessment
- All service areas covered
- Personalized treatment plan
- Prescription if appropriate
Specialized Consultation
Skin, Hair, Wellness, Labs, Galleri
First Visit
$300
Follow-Up
$150
- Focused specialty review
- Lab analysis included
- Targeted treatment approach
- Follow-up protocol
Peptide Consultation
Weight loss & metabolic therapies
First Visit
$50
Follow-Up
$30
- Metabolic assessment
- GLP-1 or peptide evaluation
- Dosing strategy
- Prescription included